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Important information about all medicines
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Carfentanil or carfentanyl (also known as 4-carbomethoxyfentanyl) is an analog of the synthetic opioid analgesic fentanyl. It was found to be four orders of magnitude or 10,000 times more potent than morphine, making it one of the most potent known and the most potent commercially used opioids
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Relationship Between Fentanyl and Carfentanil
Carfentanil’s chemical makeup is similar to fentanyl, which is another powerful opioid medication. Fentanyl is available by prescription to treat severe pain and is used in hospitals as an anesthetic. It’s 50-100 times more powerful than morphine, and is generally only given to patients who are already taking similar types of pain medication.
Fentanyl is being mixed with heroin to increase the latter drug’s potency. Drug dealers will “cut” their supply with any number of ingredients to divide it up and increase their profit. Customers have no way of knowing what a particular batch has been cut with; it could be something relatively benign, such as baking soda or baby powder, or it could be something potentially lethal, like fentanyl or even carfentantil.
Carfentanil looks like powdered heroin but is 100 times more powerful that fentanyl. Other than a powder, carfentanil is available in a tablet, blotter paper, and spray form. It can be absorbed directly through the skin or inhaled. It is so potent that one dose of carfentanil is 1 microgram (one millionth of a gram), which is about the size of a few grains of salt. Anyone coming into contact with that amount of the drug needs immediate medical attention.
Carfentanil and Opioid Addiction
Unlike other morphine derivatives, heroin, or other opioid narcotics, carfentanil does not lead to addiction. It is too powerful for humans who have not developed a tolerance to strong narcotics like heroin or fentanyl. Even for people who have struggled with addiction to powerful narcotics, a dose the size of a grain of salt can rapidly lead to an overdose and death.
However, carfentanil has been found cutting heroin and even fentanyl sold on the streets, starting in July 2016 in Ohio, when 35 overdoses and six deaths occurred in a span of three days. Law enforcement and emergency medical personnel warn that carfentanil sold illicitly looks like other drugs found on the street, including cocaine and heroin, because it is an odorless, white powder. Carfentanil, like fentanyl, has been found cutting heroin in order to increase its potency and the heroin dealer’s supply of the substance.
While adding fentanyl to heroin has led to an epidemic of overdoses, carfentanil has led to deadly overdoses much faster. For comparison, according to Elephant Care International, the dose of carfentanil safely administered to sedate a wild adult male African elephant, which can weight over 1 ton, is only 13 mg. A dose of fentanyl, 100 times less powerful than carfentanil, that can safely be administered to a human adult is up to 100 micrograms per hour – the equivalent of 0.1 mg. The dose for the elephant is equivalent to 13,000 micrograms of carfentanil, which is about 1.3 million micrograms of fentanyl. Hence, 1,000 mg of fentanyl, the equivalent in potency of 1 mg of carfentanil, will easily kill a human.
According to an article from the Washington Post, carfentanil’s deadliness can be expressed in a few ways. First, the Buffalo Field Campaign based out of Yellowstone National Park warns that humans should not eat the meat of bison who have been sedated with carfentanil, because it can enter the human’s body and cause an overdose. Second, Russian authorities used a weaponized chemical gas based on carfentanil to end a Chechen hostage crisis in 2002 and ended up killing 170 people with one dose.
The dose used to cut heroin is typically so small that forensic chemists often have a hard time finding it. Even so, that small amount is enough to send a person into an overdose. The Ohio Attorney General website recommends that forensic technicians and chemists who must field-test heroin for fentanyl or carfentanil use protective gear to avoid harming or killing themselves.